Chemotherapy Hair Loss Timeline: What to Expect | A Wig Specialist's Guide

One of the most stressful parts of a cancer diagnosis is the uncertainty of how your body will change. For many women the loss of hair is the most visible and emotional side effect of chemotherapy. Understanding the timeline of this process can help you prepare mentally and physically. It allows you to take control of a situation that often feels uncontrollable.

The Pre-Treatment Phase

Before your first infusion your hair is likely in its normal growth cycle. This is the best time to start your research. Visit a wig specialist while you still have your natural hair. This allows the specialist to see your natural color, texture, and density. They can take photos and measurements to ensure your future cranial prosthesis looks exactly like you.

Many women choose to cut their hair into a shorter style during this phase. This makes the eventual transition less dramatic. It also reduces the weight of the hair which can sometimes make the scalp feel more comfortable as treatment begins.

Days One Through Fourteen

After your first treatment you probably will not see any immediate changes. The chemotherapy drugs are working in your system to target rapidly dividing cells. Because hair follicles are some of the fastest-growing cells in the body they are unfortunately targeted alongside the cancer cells. During these first two weeks you might notice that your scalp feels slightly tender. Some women describe it as a "hair ache" or a feeling of tight skin.

The Shedding Phase: Days Fourteen to Twenty-One

For most patients the actual hair loss begins around the second or third week after the first infusion. It rarely happens all at once. You might start seeing more hair than usual on your hairbrush or in the shower. You may find clumps of hair on your pillow when you wake up in the morning.

This is often the most emotional part of the journey. The physical reality of the diagnosis becomes impossible to ignore. Many women decide to shave their heads at this point. Shaving provides a sense of empowerment. It stops the "slow shed" and allows you to move directly into the next phase of your recovery. If you choose to shave use an electric trimmer rather than a razor to avoid nicks and skin irritation.

The Maintenance Phase

Once the bulk of your hair has fallen out your scalp may remain sensitive. It is important to continue caring for your skin. Use gentle, fragrance-free cleansers. Your scalp is now exposed to the elements so you must use sunscreen or wear a hat when outdoors.

This is when your medical wig becomes your best friend. A high-quality medical wig provides a barrier between your sensitive skin and the environment. It also helps regulate your body temperature as we lose a significant amount of heat through our heads.

The Regrowth Timeline

The good news is that chemotherapy hair loss is almost always temporary. The regrowth process usually begins about three to six weeks after your final treatment.

• One Month Post-Chemo: You will likely see a fine, fuzzy layer of hair. It may be a different color or texture than you remember.

• Two Months Post-Chemo: The hair becomes more defined and covers the scalp entirely.

• Three to Six Months Post-Chemo: You will have enough growth to start thinking about a very short haircut.

• One Year Post-Chemo: Most patients have four to six inches of hair and can return to their original styling routines.

Managing the "Chemo Curl"

It is very common for hair to grow back with a different texture. Straight hair may come back curly or vice versa. This is known as the "chemo curl." It happens because the chemotherapy drugs temporarily alter the shape of the hair follicle. In most cases your hair will eventually return to its original texture after a few growth cycles. Be patient with your hair during this time. Avoid harsh chemicals or high heat until your hair is strong enough to handle it.

Finding Support

You do not have to walk through this timeline alone. Connect with support groups or find a specialist who understands the emotional weight of this transition. At Her Signature Wigs we focus on the person, not just the hair. We are here to support you from the first day of shedding to the day you no longer need our services because your natural hair has returned.

TriMonique Burton is a Certified Wig Specialist & Medical Hair Loss Expert With over two decades in the beauty industry and a specialized focus on medical hair loss since 2012, TriMonique has dedicated her career to helping women and cancer patients regain their confidence. Having served as a specialist within Florida's Cancer Institutes, Infusion, and Oncology Centers, she brings deep insight into hair replacement solutions of patients undergoing chemotherapy and radiation. As a Certified Wig Specialist, she bridges the gap between medical necessity and aesthetic beauty, ensuring every "cranial prosthesis" is a perfect fit for the patient's physical and emotional journey.

Disclaimer: The information provided on this blog is for educational and informational purposes only and is not intended as medical advice. Always seek the advice of your physician with any questions you may have regarding a medical condition or treatment.